Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways

Large-conductance and Ca(2+)-activated K(+) (BK) channels are expressed in human hepatic stellate cells (HSCs), where they have roles in normal hepatic microcirculation, as well as in portal hypertension in liver cirrhosis through the regulation of contractility in activated HSCs. Nevertheless, whet...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Yang, Linli, Han, Bo, Zhang, Man, Wang, Ya-Hui, Tao, Kun, Zhu, Michael X., He, Kunyan, Zhang, Zhi-Gang, Hou, Shangwei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068464/
https://ncbi.nlm.nih.gov/pubmed/32210801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00165
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