Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis

Mutations in the epigenetic regulators DNMT3A and IDH1/2 co-occur in patients with acute myeloid leukemia and lymphoma. In this study, these 2 epigenetic mutations cooperated to induce leukemia. Leukemia-initiating cells from Dnmt3a(−/−) mice that express an IDH2 neomorphic mutant have a megakaryocy...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zhang, Xiaotian, Wang, Xinyu, Wang, Xue Qing David, Su, Jianzhong, Putluri, Nagireddy, Zhou, Ting, Qu, Ying, Jeong, Mira, Guzman, Anna, Rosas, Carina, Huang, Yun, Sreekumar, Arun, Li, Wei, Goodell, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068035/
https://ncbi.nlm.nih.gov/pubmed/31932841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003330
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