DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia

Mutations in DNA methyltransferase 3A (DNMT3A) are common in acute myeloid leukemia and portend a poor prognosis; thus, new therapeutic strategies are needed. The likely mechanism by which DNMT3A loss contributes to leukemogenesis is altered DNA methylation and the attendant gene expression changes;...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Rau, Rachel E., Rodriguez, Benjamin A., Luo, Min, Jeong, Mira, Rosen, Allison, Rogers, Jason H., Campbell, Carly T., Daigle, Scott R., Deng, Lishing, Song, Yongcheng, Sweet, Steve, Chevassut, Timothy, Andreeff, Michael, Kornblau, Steven M., Li, Wei, Goodell, Margaret A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990856/
https://ncbi.nlm.nih.gov/pubmed/27335278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-684225
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