DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia

Mutations in DNA methyltransferase 3A (DNMT3A) are common in acute myeloid leukemia and portend a poor prognosis; thus, new therapeutic strategies are needed. The likely mechanism by which DNMT3A loss contributes to leukemogenesis is altered DNA methylation and the attendant gene expression changes;...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Rau, Rachel E., Rodriguez, Benjamin A., Luo, Min, Jeong, Mira, Rosen, Allison, Rogers, Jason H., Campbell, Carly T., Daigle, Scott R., Deng, Lishing, Song, Yongcheng, Sweet, Steve, Chevassut, Timothy, Andreeff, Michael, Kornblau, Steven M., Li, Wei, Goodell, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990856/
https://ncbi.nlm.nih.gov/pubmed/27335278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-684225
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