Crystal structure of a lipin/Pah phosphatidic acid phosphatase

Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Inactivating mutations cause rhabdomyolysis, autoinflammatory disease, and aberrant fat storage. Disease-mutations cluster within the conserved N-Lip and C-Lip regions t...

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Udgivet i:Nat Commun
Main Authors: Khayyo, Valerie I., Hoffmann, Reece M., Wang, Huan, Bell, Justin A., Burke, John E., Reue, Karen, Airola, Michael V. V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066176/
https://ncbi.nlm.nih.gov/pubmed/32161260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15124-z
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