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Crystal structure of a lipin/Pah phosphatidic acid phosphatase
Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Inactivating mutations cause rhabdomyolysis, autoinflammatory disease, and aberrant fat storage. Disease-mutations cluster within the conserved N-Lip and C-Lip regions t...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7066176/ https://ncbi.nlm.nih.gov/pubmed/32161260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15124-z |
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