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A hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in rats
Mathematical modelling remains a useful tool to study the impact of transporters on overall and intracellular drug disposition. The impact of organic anion transporter protein mediated uptake on atorvastatin systemic and intracellular pharmacokinetics, specifically distribution volume, was studied i...
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| Опубликовано в: : | Xenobiotica |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7065931/ https://ncbi.nlm.nih.gov/pubmed/31530243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2019.1668982 |
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