Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein

The glycoproteins of hepatitis C virus, E1E2, are unlike any other viral fusion machinery yet described, and are the current focus of immunogen design in HCV vaccine development; thus, making E1E2 both scientifically and medically important. We used pre-existing, but fragmentary, structures to model...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Stejskal, Lenka, Lees, William D., Moss, David S., Palor, Machaela, Bingham, Richard J., Shepherd, Adrian J., Grove, Joe
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065822/
https://ncbi.nlm.nih.gov/pubmed/32109245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007710
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