Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies exploring protein haptenation by amoxicillin, we observe...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Pajares, María A., Zimmerman, Tahl, Sánchez-Gómez, Francisco J., Ariza, Adriana, Torres, María J., Blanca, Miguel, Cañada, F. Javier, Montañez, María I., Pérez-Sala, Dolores
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065267/
https://ncbi.nlm.nih.gov/pubmed/32210804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00189
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