Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies exploring protein haptenation by amoxicillin, we observe...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Pajares, María A., Zimmerman, Tahl, Sánchez-Gómez, Francisco J., Ariza, Adriana, Torres, María J., Blanca, Miguel, Cañada, F. Javier, Montañez, María I., Pérez-Sala, Dolores
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065267/
https://ncbi.nlm.nih.gov/pubmed/32210804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00189
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