HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

Heart failure with preserved ejection fraction (HFpEF) is a major health problem without effective therapies. This study assessed the effects of histone deacetylase (HDAC) inhibition on cardiopulmonary structure, function, and metabolism in a large mammalian (feline) model of pressure overload that...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Wallner, Markus, Eaton, Deborah M., Berretta, Remus M., Liesinger, Laura, Schittmayer, Matthias, Gindlhuber, Juergen, Wu, Jichuan, Jeong, Mark Y., Lin, Ying H., Borghetti, Giulia, Baker, Sandy T., Zhao, Huaqing, Pfleger, Jessica, Blass, Sandra, Rainer, Peter P., von Lewinski, Dirk, Bugger, Heiko, Mohsin, Sadia, Graier, Wolfgang F., Zirlik, Andreas, McKinsey, Timothy A., Birner-Gruenberger, Ruth, Wolfson, Marla R., Houser, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065257/
https://ncbi.nlm.nih.gov/pubmed/31915304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay7205
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