HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

Heart failure with preserved ejection fraction (HFpEF) is a major health problem without effective therapies. This study assessed the effects of histone deacetylase (HDAC) inhibition on cardiopulmonary structure, function, and metabolism in a large mammalian (feline) model of pressure overload that...

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Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Wallner, Markus, Eaton, Deborah M., Berretta, Remus M., Liesinger, Laura, Schittmayer, Matthias, Gindlhuber, Juergen, Wu, Jichuan, Jeong, Mark Y., Lin, Ying H., Borghetti, Giulia, Baker, Sandy T., Zhao, Huaqing, Pfleger, Jessica, Blass, Sandra, Rainer, Peter P., von Lewinski, Dirk, Bugger, Heiko, Mohsin, Sadia, Graier, Wolfgang F., Zirlik, Andreas, McKinsey, Timothy A., Birner-Gruenberger, Ruth, Wolfson, Marla R., Houser, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065257/
https://ncbi.nlm.nih.gov/pubmed/31915304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay7205
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