JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

More than 30% of genes in higher eukaryotes are regulated by promoter-proximal pausing of RNA polymerase II (Pol II). Phosphorylation of Pol II CTD by positive transcription elongation factor b (P-TEFb) is a necessary precursor event that enables productive transcription elongation. The exact mechan...

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Vydáno v:eLife
Hlavní autoři: Lee, Schuyler, Liu, Haolin, Hill, Ryan, Chen, Chunjing, Hong, Xia, Crawford, Fran, Kingsley, Molly, Zhang, Qianqian, Liu, Xinjian, Chen, Zhongzhou, Lengeling, Andreas, Bernt, Kathrin Maria, Marrack, Philippa, Kappler, John, Zhou, Qiang, Li, Chuan-Yuan, Xue, Yuhua, Hansen, Kirk, Zhang, Gongyi
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064345/
https://ncbi.nlm.nih.gov/pubmed/32048991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53930
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