JMJD5 couples with CDK9 to release the paused RNA polymerase II

More than 30% of genes in higher eukaryotes are regulated by RNA polymerase II (Pol II) promoter proximal pausing. Pausing is released by the positive transcription elongation factor complex (P-TEFb). However, the exact mechanism by which this occurs and whether phosphorylation of the carboxyl-termi...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Liu, Haolin, Ramachandran, Srinivas, Fong, Nova, Phang, Tzu, Lee, Schuyler, Parsa, Pirooz, Liu, Xinjian, Harmacek, Laura, Danhorn, Thomas, Song, Tengyao, Oh, Sangphil, Zhang, Qianqian, Chen, Zhongzhou, Zhang, Qian, Tu, Ting-Hui, Happoldt, Carrie, O’Conner, Brian, Janknecht, Ralf, Li, Chuan-Yuan, Marrack, Philippa, Kappler, John, Leach, Sonia, Zhang, Gongyi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443887/
https://ncbi.nlm.nih.gov/pubmed/32747552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005745117
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