Comparing PI3K/Akt Inhibitors Used in Ovarian Cancer Treatment

Epithelial ovarian carcinoma (EOC) is the most lethal gynecological malignancy. Herein, we sought to determine the efficacy of phosphoinositide 3-kinase (PI3K)/Akt inhibition using three AZD compounds in a NOD-SCID xenograft mouse model and Akt regulation in a panel of eight ovarian cancer cell line...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Wu, Yi-Hui, Huang, Yu-Fang, Chen, Chien-Chin, Huang, Chia-Yen, Chou, Cheng-Yang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063971/
https://ncbi.nlm.nih.gov/pubmed/32194423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00206
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