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Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression

We studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with p...

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Publicado en:Cell Death Dis
Main Authors: Wu, Yi-Hui, Huang, Yu-Fang, Chen, Chien-Chin, Chou, Cheng-Yang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459878/
https://ncbi.nlm.nih.gov/pubmed/30975980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1555-8
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