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High-resolution modeling of the selection on local mRNA folding strength in coding sequences across the tree of life

BACKGROUND: mRNA can form local secondary structure within the protein-coding sequence, and the strength of this structure is thought to influence gene expression regulation. Previous studies suggest that secondary structure strength may be maintained under selection, but the details of this phenome...

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Publicat a:Genome Biol
Autors principals: Peeri, Michael, Tuller, Tamir
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063772/
https://ncbi.nlm.nih.gov/pubmed/32151272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01971-y
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