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High-resolution modeling of the selection on local mRNA folding strength in coding sequences across the tree of life

BACKGROUND: mRNA can form local secondary structure within the protein-coding sequence, and the strength of this structure is thought to influence gene expression regulation. Previous studies suggest that secondary structure strength may be maintained under selection, but the details of this phenome...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Peeri, Michael, Tuller, Tamir
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063772/
https://ncbi.nlm.nih.gov/pubmed/32151272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01971-y
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