GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rapidly progressive, fatal lung disease that affects older adults. One of the detrimental natural histories of IPF is acute exacerbation of IPF (AE-IPF), of which bacterial infection is reported to play an important role. However, the mechanism by...

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Bibliographic Details
Published in:Thorax
Main Authors: Cho, Soo Jung, Moon, Jong-Seok, Nikahira, Kiichi, Yun, Ha Seon, Harris, Rebecca, Hong, Kyung Sook, Huang, Huarong, Choi, Augustine M K, Stout-Delgado, Heather
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2020
Subjects:
Interstitial Lung Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063401/
https://ncbi.nlm.nih.gov/pubmed/31822523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-213571
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