The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells. Clonal haematopoiesis increases the risk of myocardial infarction and stroke independently of traditional risk factors(1). Among the comm...

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Veröffentlicht in:Nature
Hauptverfasser: Fidler, Trevor P., Xue, Chenyi, Yalcinkaya, Mustafa, Hardaway, Brian, Abramowicz, Sandra, Xiao, Tong, Liu, Wenli, Thomas, David G., Hajebrahimi, Mohammad Ali, Pircher, Joachim, Silvestre-Roig, Carlos, Kotini, Andriana G., Luchsinger, Larry L., Wei, Ying, Westerterp, Marit, Snoeck, Hans-Willem, Papapetrou, Eirini P., Schulz, Christian, Massberg, Steffen, Soehnlein, Oliver, Ebert, Benjamin, Levine, Ross L., Reilly, Muredach P., Libby, Peter, Wang, Nan, Tall, Alan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038646/
https://ncbi.nlm.nih.gov/pubmed/33731931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03341-5
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