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Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy
Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic lethality in cells where the homologous recombinat...
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| Publicado en: | Front Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7062869/ https://ncbi.nlm.nih.gov/pubmed/32194409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00170 |
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