Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy

Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic lethality in cells where the homologous recombinat...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Jannetti, Stephen A., Zeglis, Brian M., Zalutsky, Michael R., Reiner, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062869/
https://ncbi.nlm.nih.gov/pubmed/32194409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00170
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