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Non-homologous DNA end joining and alternative pathways to double-strand break repair

DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous DNA end joining (NHEJ) pathway. Defects in NH...

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書目詳細資料
發表在:Nat Rev Mol Cell Biol
Main Authors: Chang, Howard H. Y., Pannunzio, Nicholas R., Adachi, Noritaka, Lieber, Michael R.
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062608/
https://ncbi.nlm.nih.gov/pubmed/28512351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2017.48
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