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Non-homologous DNA end joining and alternative pathways to double-strand break repair
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous DNA end joining (NHEJ) pathway. Defects in NH...
Gardado en:
| Publicado en: | Nat Rev Mol Cell Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7062608/ https://ncbi.nlm.nih.gov/pubmed/28512351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2017.48 |
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