A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation

Phosphorylation of specific residues in the activation loops of AGC kinase group (protein kinase A, G, and C families) is required for activity of most of these kinases, including the catalytic subunit of PKA (PKAc). Although many phosphorylated AGC kinases are sensitive to phosphatase-mediated deph...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Chan, Tung O., Armen, Roger S., Yadav, Santosh, Shah, Sushrut, Zhang, Jin, Tiegs, Brian C., Keny, Nikhil, Blumhof, Brian, Deshpande, Deepak A., Rodeck, Ulrich, Penn, Raymond B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062156/
https://ncbi.nlm.nih.gov/pubmed/31964716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010004
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