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Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
The Akt protein kinase, also known as protein kinase B, plays key roles in insulin receptor signalling and regulates cell growth, survival and metabolism. Recently, we described a mechanism to enhance Akt phosphorylation that restricts access of cellular phosphatases to the Akt activation loop (Thr(...
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| Udgivet i: | Biochem J |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4676407/ https://ncbi.nlm.nih.gov/pubmed/26201515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150325 |
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