β-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent

Inhaled β-agonists are effective at reversing bronchoconstriction in asthma, but the mechanism by which they exert this effect is unclear and controversial. PKA is the historically accepted effector, although this assumption is made on the basis of associative and not direct evidence. Recent studies...

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Hlavní autoři: Morgan, Sarah J., Deshpande, Deepak A., Tiegs, Brian C., Misior, Anna M., Yan, Huandong, Hershfeld, Alena V., Rich, Thomas C., Panettieri, Reynold A., An, Steven S., Penn, Raymond B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132805/
https://ncbi.nlm.nih.gov/pubmed/24973219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.557652
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