Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle

To clarify the potential utility of targeting GRK2/3-mediated desensitization as a means of manipulating airway smooth muscle (ASM) contractile state, we assessed the specificity of GRK2/3 regulation of procontractile and relaxant G-protein-coupled receptors in ASM. Functional domains of GRK2/3 were...

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Detalhes bibliográficos
Main Authors: Deshpande, Deepak A., Yan, Huandong, Kong, Kok-Choi, Tiegs, Brian C., Morgan, Sarah J., Pera, Tonio, Panettieri, Reynold A., Eckhart, Andrea D., Penn, Raymond B.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898647/
https://ncbi.nlm.nih.gov/pubmed/24132623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-240226
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