PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ

The Hippo pathway regulates organ size by controlling both cell proliferation and apoptosis. TAZ functions as a transcriptional co-activator downstream of the Hippo pathway and has been implicated in human cancer development. A key step in the Hippo-TAZ pathway is phosphorylation of TAZ by LATS kina...

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Hlavní autoři: Liu, Chen-Ying, Lv, Xianbo, Li, Tingting, Xu, Yanping, Zhou, Xin, Zhao, Shimin, Xiong, Yue, Lei, Qun-Ying, Guan, Kun-Liang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037669/
https://ncbi.nlm.nih.gov/pubmed/21189257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194019
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