PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction

The Hippo pathway plays a major role in organ size control, and its dysregulation contributes to tumorigenesis. The major downstream effectors of the Hippo pathway are the YAP/TAZ transcription co-activators, which are phosphorylated and inhibited by the Hippo pathway kinase LATS1/2. Here, we report...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Rep
Prif Awduron: Lv, Xian-Bo, Liu, Chen-Ying, Wang, Zhen, Sun, Yi-Ping, Xiong, Yue, Lei, Qun-Ying, Guan, Kun-Liang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley & Sons, Ltd 2015
Pynciau:
Scientific Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552490/
https://ncbi.nlm.nih.gov/pubmed/26116754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439951
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