The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells

In human cancer cells that harbor mutant KRAS and WT p53 (p53), KRAS contributes to the maintenance of low p53 levels. Moreover, KRAS depletion stabilizes and reactivates p53 and thereby inhibits malignant transformation. However, the mechanism by which KRAS regulates p53 is largely unknown. Recentl...

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Publicat a:J Biol Chem
Autors principals: Yang, Hua, Xiang, Shengyan, Kazi, Aslamuzzaman, Sebti, Said M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062149/
https://ncbi.nlm.nih.gov/pubmed/32001619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011930
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