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Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation
Ral GTPases are critical effectors of Ras, yet the molecular mechanism by which they induce malignant transformation is not well understood. In this study, we found the expression of K-Ras, RalB, and sometimes RalA, but not AKT1/2 and c-Raf, to be required for maintaining low levels of p53 in human...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4223330/ https://ncbi.nlm.nih.gov/pubmed/25210032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565796 |
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