Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells

Long interspersed element-1 (LINE-1, L1) sequences, which comprise about 17% of human genome, are the product of one of the most active types of mobile DNAs in modern humans. LINE-1 insertion alleles can cause inherited and de novo genetic diseases, and LINE-1-encoded proteins are highly expressed i...

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Vydáno v:Philos Trans R Soc Lond B Biol Sci
Hlavní autoři: McKerrow, Wilson, Tang, Zuojian, Steranka, Jared P., Payer, Lindsay M., Boeke, Jef D., Keefe, David, Fenyö, David, Burns, Kathleen H., Liu, Chunhong
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061987/
https://ncbi.nlm.nih.gov/pubmed/32075555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2019.0335
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