Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific forms of Pyruvate Kinase found in mammals: PK...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Zahra, Kulsoom, Dey, Tulika, Ashish, Mishra, Surendra Pratap, Pandey, Uma
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061896/
https://ncbi.nlm.nih.gov/pubmed/32195169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00159
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