Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function

Thrombin, a procoagulant protease, cleaves and activates protease-activated receptor-1 (PAR1) to promote inflammatory responses and endothelial dysfunction. In contrast, activated protein C (APC), an anticoagulant protease, activates PAR1 through a distinct cleavage site and promotes anti-inflammato...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Lin, Ying, Wozniak, Jacob M., Grimsey, Neil J., Girada, Sravan, Patwardhan, Anand, Molinar-Inglis, Olivia, Smith, Thomas H., Lapek, John D., Gonzalez, David J., Trejo, JoAnn
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060683/
https://ncbi.nlm.nih.gov/pubmed/32071217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917295117
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