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Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells

The stochasticity of gene expression presents significant challenges to the modeling of genetic networks. A two-state model describing promoter switching, transcription, and messenger RNA (mRNA) decay is the standard model of stochastic mRNA dynamics in eukaryotic cells. Here, we extend this model t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cao, Zhixing, Grima, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060679/
https://ncbi.nlm.nih.gov/pubmed/32071224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910888117
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