The brain‐penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion‐induced emesis in Suncus murinus (house musk shrew)

BACKGROUND AND PURPOSE: HM01, a novel, orally bioavailable, brain‐penetrating agonist of ghrelin receptors, ameliorates emesis in Suncus murinus. This study compared HM01's activity against motion sickness with that of the less brain‐penetrating ghrelin receptor agonist, HM02. EXPERIMENTAL APPR...

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Pubblicato in:Br J Pharmacol
Autori principali: Tu, Longlong, Lu, Zengbing, Ngan, Man P., Lam, Francis F.Y., Giuliano, Claudio, Lovati, Emanuela, Pietra, Claudio, Rudd, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060360/
https://ncbi.nlm.nih.gov/pubmed/31722444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14924
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