The brain‐penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion‐induced emesis in Suncus murinus (house musk shrew)

BACKGROUND AND PURPOSE: HM01, a novel, orally bioavailable, brain‐penetrating agonist of ghrelin receptors, ameliorates emesis in Suncus murinus. This study compared HM01's activity against motion sickness with that of the less brain‐penetrating ghrelin receptor agonist, HM02. EXPERIMENTAL APPR...

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Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Tu, Longlong, Lu, Zengbing, Ngan, Man P., Lam, Francis F.Y., Giuliano, Claudio, Lovati, Emanuela, Pietra, Claudio, Rudd, John A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060360/
https://ncbi.nlm.nih.gov/pubmed/31722444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14924
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