The brain‐penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion‐induced emesis in Suncus murinus (house musk shrew)

BACKGROUND AND PURPOSE: HM01, a novel, orally bioavailable, brain‐penetrating agonist of ghrelin receptors, ameliorates emesis in Suncus murinus. This study compared HM01's activity against motion sickness with that of the less brain‐penetrating ghrelin receptor agonist, HM02. EXPERIMENTAL APPR...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Tu, Longlong, Lu, Zengbing, Ngan, Man P., Lam, Francis F.Y., Giuliano, Claudio, Lovati, Emanuela, Pietra, Claudio, Rudd, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060360/
https://ncbi.nlm.nih.gov/pubmed/31722444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14924
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