The brain‐penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion‐induced emesis in Suncus murinus (house musk shrew)

BACKGROUND AND PURPOSE: HM01, a novel, orally bioavailable, brain‐penetrating agonist of ghrelin receptors, ameliorates emesis in Suncus murinus. This study compared HM01's activity against motion sickness with that of the less brain‐penetrating ghrelin receptor agonist, HM02. EXPERIMENTAL APPR...

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Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Tu, Longlong, Lu, Zengbing, Ngan, Man P., Lam, Francis F.Y., Giuliano, Claudio, Lovati, Emanuela, Pietra, Claudio, Rudd, John A.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060360/
https://ncbi.nlm.nih.gov/pubmed/31722444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14924
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