Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (house musk shrew)

Background and Aims: Chemotherapy-induced acute and delayed emesis involves the activation of multiple pathways, with 5-hydroxytryptamine (5-HT; serotonin) playing a major role in the initial response. Substance P tachykinin NK1 receptor antagonists can reduce emesis induced by disparate emetic chal...

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Main Authors: John A Rudd, Man P. Ngan, Zengbing Lu, Guy A. Higgins, Claudio Giuliano, Emanuela Lovati, Claudio Pietra
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Pharmacology
Assuntos:
Nausea
Vomiting
chemotherapy
ferret
5-HT3
NK1
Acceso en liña:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00263/full
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