Reciprocal upregulation of hypoxia inducible factor-1α and persistently enhanced placental adenosine signaling contribute to the pathogenesis of preeclampsia

Recent evidence indicates that elevated placental adenosine signaling contributes to preeclampsia (PE). However, the molecular basis for the chronically enhanced placental adenosine signaling in PE remains unclear. Here we report that hypoxia inducible factor-1α (HIF-1α) is crucial for the enhanceme...

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Vydáno v:FASEB J
Hlavní autoři: Iriyama, Takayuki, Wang, Wei, Parchim, Nicholas F., Sayama, Seisuke, Kumasawa, Keiichi, Nagamatsu, Takeshi, Song, Anren, Xia, Yang, Kellems, Rodney E
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060108/
https://ncbi.nlm.nih.gov/pubmed/31930569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902583R
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