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Hypoxia-independent up-regulation of placental HIF-1α gene expression contributes to the pathogenesis of preeclampsia

Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial response to hypoxia, while chronically elevated HIF-1α is associated with multiple disease conditions including preeclampsia (PE), a serious hypertensive disease of pregnancy. However, the molecular basis underl...

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Bibliografiske detaljer
Udgivet i:Hypertension
Main Authors: Iriyama, Takayuki, Wang, Wei, Parchim, Nicholas F., Song, Anren, Blackwell, Sean C., Sibai, Baha M., Kellems, Rodney E, Xia, Yang
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859813/
https://ncbi.nlm.nih.gov/pubmed/25847948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05314
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