Metabolic pathway analysis and effectiveness of tamoxifen in Danish breast cancer patients

BACKGROUND: Tamoxifen and its metabolites compete with estrogen to occupy the estrogen receptor. The conventional dose of adjuvant tamoxifen overwhelms estrogen in this competition, reducing breast cancer recurrence risk by nearly half. Phase 1 metabolism generates active tamoxifen metabolites and p...

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Detalhes bibliográficos
Publicado no:Cancer Epidemiol Biomarkers Prev
Main Authors: Ahern, Thomas P., Collin, Lindsay J., Baurley, James W., Kjærsgaard, Anders, Nash, Rebecca, Maliniak, Maret L., Damkier, Per, Zwick, Michael E., Isett, R. Benjamin, Christiansen, Peer M., Ejlertsen, Bent, Lauridsen, Kristina L., Christensen, Kristina B., Silliman, Rebecca A., Sørensen, Henrik T., Tramm, Trine, Hamilton-Dutoit, Stephen, Lash, Timothy L., Cronin-Fenton, Deirdre
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060091/
https://ncbi.nlm.nih.gov/pubmed/31932415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-19-0833
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