Metabolic pathway analysis and effectiveness of tamoxifen in Danish breast cancer patients

BACKGROUND: Tamoxifen and its metabolites compete with estrogen to occupy the estrogen receptor. The conventional dose of adjuvant tamoxifen overwhelms estrogen in this competition, reducing breast cancer recurrence risk by nearly half. Phase 1 metabolism generates active tamoxifen metabolites and p...

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Pubblicato in:Cancer Epidemiol Biomarkers Prev
Autori principali: Ahern, Thomas P., Collin, Lindsay J., Baurley, James W., Kjærsgaard, Anders, Nash, Rebecca, Maliniak, Maret L., Damkier, Per, Zwick, Michael E., Isett, R. Benjamin, Christiansen, Peer M., Ejlertsen, Bent, Lauridsen, Kristina L., Christensen, Kristina B., Silliman, Rebecca A., Sørensen, Henrik T., Tramm, Trine, Hamilton-Dutoit, Stephen, Lash, Timothy L., Cronin-Fenton, Deirdre
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060091/
https://ncbi.nlm.nih.gov/pubmed/31932415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-19-0833
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