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Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy
Tamoxifen reduces the rate of breast cancer recurrence by approximately a half. Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6). Tamoxifen is a substrate for ATP-binding cassette transporter proteins. We review tamox...
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| Publicado no: | Future Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4319217/ https://ncbi.nlm.nih.gov/pubmed/24328412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.13.168 |
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