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Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy
Tamoxifen reduces the rate of breast cancer recurrence by approximately a half. Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6). Tamoxifen is a substrate for ATP-binding cassette transporter proteins. We review tamox...
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| Vydáno v: | Future Oncol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4319217/ https://ncbi.nlm.nih.gov/pubmed/24328412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.13.168 |
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