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Analysis of Electrochemical Properties of S-Adenosyl-l-methionine and Implications for Its Role in Radical SAM Enzymes

[Image: see text] S-Adenosyl-l-methionine (SAM) is the central cofactor in the radical SAM enzyme superfamily, responsible for a vast number of transformations in primary and secondary metabolism. In nearly all of these reactions, the reductive cleavage of SAM is proposed to produce a reactive speci...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Miller, Sven A., Bandarian, Vahe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059804/
https://ncbi.nlm.nih.gov/pubmed/31283208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b00933
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