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P-selectin blockade ameliorates lupus nephritis in MRL/lpr mice through improving renal hypoxia and evaluation using BOLD-MRI

BACKGROUND: Lupus nephritis is one of the most common and severe complications of systemic lupus erythematosus, of which poor prognosis is indicated by aggravated renal hypoxia and tubulointerstitial fibrosis. Cell adhesion molecules play a key role in the progression of lupus nephritis tubulointers...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Zhang, Liwen, Chen, Sheng, Liu, Yan, Xu, Xueqin, Zhang, Qianying, Shao, Shuxin, Wang, Weiming, Li, Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059679/
https://ncbi.nlm.nih.gov/pubmed/32138730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02284-1
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