Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria

Hutchinson–Gilford progeria is a premature aging syndrome caused by a truncated form of lamin A called progerin. Progerin expression results in a variety of cellular defects including heterochromatin loss, DNA damage, impaired proliferation and premature senescence. It remains unclear how these diff...

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Détails bibliographiques
Publié dans:Aging Cell
Auteurs principaux: Chojnowski, Alexandre, Ong, Peh Fern, Foo, Mattheus Xing Rong, Liebl, David, Hor, Louis‐Peter, Stewart, Colin L., Dreesen, Oliver
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059134/
https://ncbi.nlm.nih.gov/pubmed/32087607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13108
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