Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways

Whether smoking-associated DNA methylation has a causal effect on lung function has not been thoroughly evaluated. We first investigated the causal effects of 474 smoking-associated CpGs on forced expiratory volume in 1 s (FEV(1)) in UK Biobank (n = 321,047) by using two-sample Mendelian randomizati...

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Bibliografski detalji
Izdano u:Am J Hum Genet
Glavni autori: Jamieson, Emily, Korologou-Linden, Roxanna, Wootton, Robyn E., Guyatt, Anna L., Battram, Thomas, Burrows, Kimberley, Gaunt, Tom R., Tobin, Martin D., Munafò, Marcus, Davey Smith, George, Tilling, Kate, Relton, Caroline, Richardson, Tom G., Richmond, Rebecca C.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058834/
https://ncbi.nlm.nih.gov/pubmed/32084330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.01.015
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