Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways

Whether smoking-associated DNA methylation has a causal effect on lung function has not been thoroughly evaluated. We first investigated the causal effects of 474 smoking-associated CpGs on forced expiratory volume in 1 s (FEV(1)) in UK Biobank (n = 321,047) by using two-sample Mendelian randomizati...

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Udgivet i:Am J Hum Genet
Main Authors: Jamieson, Emily, Korologou-Linden, Roxanna, Wootton, Robyn E., Guyatt, Anna L., Battram, Thomas, Burrows, Kimberley, Gaunt, Tom R., Tobin, Martin D., Munafò, Marcus, Davey Smith, George, Tilling, Kate, Relton, Caroline, Richardson, Tom G., Richmond, Rebecca C.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058834/
https://ncbi.nlm.nih.gov/pubmed/32084330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.01.015
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