Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways

Whether smoking-associated DNA methylation has a causal effect on lung function has not been thoroughly evaluated. We first investigated the causal effects of 474 smoking-associated CpGs on forced expiratory volume in 1 s (FEV(1)) in UK Biobank (n = 321,047) by using two-sample Mendelian randomizati...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Jamieson, Emily, Korologou-Linden, Roxanna, Wootton, Robyn E., Guyatt, Anna L., Battram, Thomas, Burrows, Kimberley, Gaunt, Tom R., Tobin, Martin D., Munafò, Marcus, Davey Smith, George, Tilling, Kate, Relton, Caroline, Richardson, Tom G., Richmond, Rebecca C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058834/
https://ncbi.nlm.nih.gov/pubmed/32084330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.01.015
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