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Cryo-EM structure of full-length HIV-1 Env bound with the Fab of antibody PG16
The HIV-1 envelope protein (Env) is the target of neutralizing antibodies and the template for vaccine immunogen design. The dynamic conformational equilibrium of trimeric Env influences its antigenicity and potential immunogenicity. Antibodies that bind at the trimer apex stabilize a “closed” confo...
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| 發表在: | J Mol Biol |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7058448/ https://ncbi.nlm.nih.gov/pubmed/31931014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.11.028 |
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