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Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT(3A) receptor
Serotonin receptor (5-HT(3A)R)(1), a cationic pentameric ligand-gated ion channel (pLGIC), is the clinical target for management of nausea and vomiting associated with radiation and chemotherapies(2). Upon binding, serotonin induces a global conformational change encompassing the ligand-binding extr...
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| Izdano u: | Nature |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6237196/ https://ncbi.nlm.nih.gov/pubmed/30401837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0660-7 |
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