Cryo-EM structure of 5-HT(3A) receptor in its resting conformation

Serotonin receptors (5-HT(3A)R) directly regulate gut movement, and drugs that inhibit 5-HT(3A)R function are used to control emetic reflexes associated with gastrointestinal pathologies and cancer therapies. The 5-HT(3A)R function involves a finely tuned orchestration of three domain movements that...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Basak, Sandip, Gicheru, Yvonne, Samanta, Amrita, Molugu, Sudheer Kumar, Huang, Wei, Fuente, Maria la de, Hughes, Taylor, Taylor, Derek J., Nieman, Marvin T., Moiseenkova-Bell, Vera, Chakrapani, Sudha
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802770/
https://ncbi.nlm.nih.gov/pubmed/29410406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02997-4
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